The prevalence of adult cognitive disorders will dramatically rise over the next 25 years due to the aging population. Clinical research on adult cognitive disorders has rapidly evolved, including evidence of new adult cognitive disorders and greater insight into the clinical presentation, mechanism, diagnosis, and treatment of established diseases. The Oxford Handbook of Adult Cognitive Disorders is an up-to-date, scholarly, and comprehensive volume covering most diseases, conditions, and injuries resulting in impairments in cognitive function in adults. Topics covered include normal cognitive and brain aging, the impact of medical disorders and psychiatric illnesses on cognitive function, adult neurodevelopmental disorders, and various neurological conditions. This Handbook also provides a section on unique perspectives and special considerations for clinicians and clinical researchers, covering topics such as cognitive reserve, genetics, diversity, and neuroethics. Readers will be able to draw upon this volume to facilitate clinical practice (including differential diagnosis, treatment recommendations, assessment practices), and to obtain an in-depth review of current research across a wide spectrum of disorders, provided by leaders in their fields. The Oxford Handbook of Adult Cognitive Disorders is a one-of a kind resource appropriate for both clinicians and clinical researchers, from advanced trainees to seasoned professionals. Table of Contents Part I. Introduction 1. Overview of the Oxford Handbook of Adult Cognitive Disorders Michael L. Alosco and Robert A. Stern 2. Normal Cognitive and Brain Aging Stephanie L. Leal and Michael A. Yassa Part II. The Spectrum of Adult Cognitive Disorders Medical Disorders and Neurocognition 3. HIV-Associated Neurocognitive Disorders Jennifer E. Iudicello, Erin E. Morgan, Mariam A. Hussain, C. Wei-Ming Watson, and Robert K. Heaton 4. Cancer and Cancer Treatment-Related Cognitive Impairment James C. Root, Elizabeth Ryan, and Tim A. Ahles 5. Effects of Cardiovascular Disease and Related Risk Factors on Neurocognition Spencer W. Liebel and Lawrence H. Sweet 6. Type 1 and Type 2 Diabetes and the Brain Olga Neyman and Tamara Hershey 7. Chronic Kidney Disease and Neurocognition David A. Drew and Daniel E. Weiner 8. Cognitive Impairment in Liver Disease Ganesh Pantham and Kevin D. Mullen 9. Pulmonary Disorders Sachelle Ruickbie, Charles Sharp, and James W. Dodd 10. Neurocognition in Menopause and Reproductive Disorders Kelly N. Morgan, Kejal Kantarci, Sanjay Asthana,and Carey E. Gleason 11. Neurotoxicant Exposures Roberta F. White, Caitlin Brand, Birgit Claus Henn, and Patricia A. Janulewicz Psychiatric Disorders and Neurocognition 12. Cognitive Function in Mood and Anxiety Disorder Hannah R. Snyder and Benjamin L. Hankin 13. Neuropsychology of Posttraumatic Stress Disorder Jennifer J. Vasterling and Gabriel S. Walt 14. Cognition in Schizophrenia Spectrum and Other Psychotic Disorders Martin Strassnig and Philip D. Harvey 15. Alcohol Use Disorder: Permanent and Transient Effects on the Brain and Neuropsychological Functions Anne-Pascale Le Berre, Alice Laniepce, Shailendra Segobin, Anne-Lise Pitel, and Edith V. Sullivan 16. Sleep Disorders and Neurocognition Alexandra M. Villagran and Michael K. Scullin Adult Neurodevelopmental Disorders 17. Autism Spectrum Disorders in Adults Charlotte M. Pretzsch, James L. Findon, and Declan G. Murphy 18. Cognition, Aging, and the Development of Dementia in Down Syndrome Allison Caban-Holt, David K. Powell, Amelia J. Anderson-Mooney,William Robertson, Donita Lightner, Frederick A. Schmitt, and Elizabeth Head 19. Adult Attention-Deficit/Hyperactivity Disorder Beth Krone, Amanda Kirschenbaum, Thomas Yang, Amy Glick, Alexander Newcorn, and Jeffrey H. Newcorn Neurological Disorders 20. Cognitive Functions in Patients with Brain Tumors Denise D. Correa 21. Hydrocephalus Aamir A. Khan, David Solomon, and Abhay R. Moghekar 22. Seizure Disorders Danny M. Tam and William B. Barr 23. Multiple Sclerosis Brian M. Sandroff and John DeLuca 24. Traumatic Brain Injury Irene Cristofori and Jordan Grafman 25. Concussion 5 Breton M. Asken and Michael A. McCrea 26. Alzheimer's Disease Dorene M. Rentz, Irina Orlovsky, Emily Kilpatrick, and Kathryn V. Papp 27. The Spectrum of Cerebrovascular Disease and Associated Cognitive Decline Victoria J. Williams, Steven E. Arnold, and David H. Salat 28. Parkinson's Disease and Parkinson-Plus Syndromes Alice Cronin-Golomb, Gretchen O. Reynolds, Robert D. Salazar, and Marie-Hélène Saint-Hilaire 29. Chronic Traumatic Encephalopathy Jason W. Adams, Ian Mahar, and Ann C. McKee 30. Huntington Disease Jane S. Paulsen 31. Frontotemporal Dementia Andrea G. Alioto, Christie C. Mead, Alicia B. Vanden Bussche, Adam M. Staffaroni, and Joel H. Kramer 32. Rapidly Progressive Dementia: Human Prion Diseases and an Approach for Evaluating Non-Prion Etiologies David N. Soleimani-Meigooni and Michael D. Geschwind 33. Alcohol Dementia, Wernicke's Encephalopathy, and Korsakoff's Syndrome Marlene Oscar-Berman and Nasim Maleki Part III. Perspectives and Considerations for the Clinical Researcher in Adult Cognitive Disorders 34. Overview of the Reserve Concept in the Context of Cognitive Aging Preeti Sunderaraman and Yaakov Stern 35. Neuropsychological Evaluation Robin C. Hilsabeck and Beth C. Arredondo 36. Genetics of Adult Cognitive Disorders Laney Evers, Courtney Verscaj, and Jesse Mez 37. Applications of Neuropathological Examination in Adult Cognitive Disorders Thor D. Stein, Victor E. Alvarez, and Bertrand R. Huber 38. Considerations for Translational Research in the Study of Adult Cognitive Disorders Erich S. Franz, Sarah E. Chancellor, and Lee E. Goldstein 39. Issues of Diversity in Cognitive Aging: A Focus on Older African Americans Lisa L. Barnes 40. Ethical Issues in Adult Cognitive Disorders Andrea Horwege, Thomas Hammeke, Anita Sue Jwa, and Allyson C. Rosen About the Editors: Michael L. Alosco, PhD, is a licensed clinical neuropsychologist and an Assistant Professor of Neurology at the Boston University School of Medicine. Dr. Alosco has more than 110 peer-reviewed publications, numerous book chapters, has received several federal and non-federal grants, is the recipient of a National Institutes of Health K23 Career Development Award, has received multiple awards from international professional organizations, and has been clinically trained in adult neuropsychology at some of the leading institutions across the country. His clinical experiences with adult cognitive disorders are diverse, ranging from outpatient memory clinics to inpatient psychiatry, and forensic settings. Robert A. Stern, PhD, is a licensed clinical neuropsychologist and a Professor of Neurology, Neurosurgery, and Anatomy & Neurobiology, at Boston University (BU) School of Medicine, where he is also the Clinical Core Director of the BU Alzheimer's Disease Center and Co-Founder and Director of Clinical Research for the BU CTE Center. Dr. Stern is an international leader in neuropsychology and clinical neuroscience and has an extensive publication record. He has had continuous grant support for over 25 years, and has developed widely used neuropsychological instruments, including the Neuropsychological Assessment Battery (NAB). He is also a pioneer clinical researcher in the field of chronic traumatic encephalopathy (CTE) and has received several grants from National Institutes of Health, the Department of Defense, and private industry to develop methods for detecting and diagnosing CTE during life. Contributors: Jason W. Adams, BS Tim A. Ahles, PhD Andrea G. Alioto, MS Michael L. Alosco, PhD Victor E. Alvarez, MD Amelia J. Anderson-Mooney, PhD Steven E. Arnold, MD Beth C. Arredondo, PhD, ABPP-CN Breton M. Asken, MS, ATC Sanjay Asthana, MD Lisa L. Barnes, PhD William B. Barr, PhD, ABPP Caitlin Brand, MPH Allison Caban-Holt, PhD Birgit Claus Henn, ScD Denise D. Correa, PhD, ABPP-CN Irene Cristofori, PhD Alice Cronin-Golomb, PhD John DeLuca, PhD James W. Dodd, MB, ChB, MRCP, PhD David A. Drew, MD, MS Laney Evers, BS James L. Findon, MSc Erich S. Franz, BS Michael D. Geschwind, MD, PhD Carey E. Gleason, PhD Amy Glick, MD Lee E. Goldstein MD, PhD Jordan Grafman, PhD Thomas Hammeke, PhD Benjamin L. Hankin, PhD Philip D. Harvey, PhD Elizabeth Head, MA, PhD Robert K. Heaton, PhD Tamara Hershey, PhD Robin C. Hilsabeck, PhD, ABPP-CN Andrea Horwege Bertrand R. Huber, MD, PhD Mariam A. Hussain, BA Jennifer E. Iudicello, PhD Patricia A. Janulewicz, DSc Anita Sue Jwa, JSM Kejal Kantarci, MD Aamir A. Khan, MBChB Emily Kilpatrick, BA Amanda Kirschenbaum, BSc Joel H. Kramer, PsyD Beth Krone, PhD Alice Laniepce, MS Anne-Pascale Le Berre, PhD Stephanie L. Leal, PhD Spencer W. Liebel, M.S Donita Lightner, MD Ian Mahar, PhD Nasim Maleki, PhD Michael A. McCrea, PhD Ann C. McKee, MD Christie C. Mead, MS Jesse Mez, MD, MS Abhay R. Moghekar, MBBS Erin E. Morgan, PhD Kelly N. Morgan, PsyD Kevin D. Mullen MD, FRCPI Prof. Declan G. Murphy, FRCPsych Alexander Newcorn, BA Jeffrey H. Newcorn, MD Olga Neyman, BS Irina Orlovsky, MA Marlene Oscar-Berman, PhD Ganesh Pantham MD, MRCP Kathryn V. Papp, PhD Jane S. Paulsen, PhD Anne-Lise Pitel, PhD David K. Powell, PhD Charlotte M. Pretzsch, MSc Dorene M. Rentz, PsyD Gretchen O. Reynolds, PhD Sarah E. Rind, BA William Robertson, MD James C. Root, PhD Allyson C. Rosen, PhD Sachelle Ruickbie, MB, ChB, MRCP Elizabeth Ryan, PhD, ABPP-CN Marie-Hélène Saint-Hilaire, MD, FRCPC David H. Salat, PhD Robert D. Salazar, MA Brian M. Sandroff, PhD Frederick A. Schmitt, PhD Michael K. Scullin, PhD Shailendra Segobin, PhD Charles Sharp, BMBCh, MD, MRCP Hannah R. Snyder, PhD David N. Soleimani-Meigooni, MD David Solomon, PhD Adam M. Staffaroni, PhD Thor D. Stein, MD, PhD Robert A. Stern, PhD Yaakov Stern, PhD Martin Strassnig, MD Edith V. Sullivan, PhD Preeti Sunderaraman, PhD Lawrence H. Sweet, PhD Danny M. Tam, PhD Alicia B. Vanden Bussche, MS Jennifer J. Vasterling, PhD Courtney Verscaj, BS Alexandra M. Villagran, MS Gabriel S. Walt, MA C. Wei-Ming Watson, BA Daniel E. Weiner, MD, MS Roberta F. White, PhD, ABPP Victoria J. Williams Ph.D Thomas Yang, MD Michael A. Yassa, PhD |