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In Search of Madness : Schizophrenia and Neuroscience
Heinrichs, R. Walter
Oxford University Press [Trade] / Hardcover / 2001-04-01 / 0195122194
Psychiatry / Toronto Authors
price: $54.95 (may be subject to change)
368 pages
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Over the last two decades, scientific articles on schizophrenia have doubled in number, and prophecies of breakthrough have appeared and receded. The result is a scattered and confusing mass of evidence that is difficult to evaluate. How much progress has really been made? Are the neurological causes of madness truly in sight?L This book evaluates the progress of schizophrenia science by summarizing what is known about how patients with the illness differ from healthy people. The tools of meta-analysis are first explained and then employed to make the strength and consistency of these differences explicit. Beginning with the study of symptoms, then moving through the search for objective disease markers, findings on the cognitive functions, structure, physiology, chemistry, and development of the brain, this book is a journey into the enigma of madness and its science. What emerges is an illness that reveals itself most strongly in thought processes, not biology.L As evidence actually becomes weaker and harder to reproduce as research moves from mind to molecule, the harvest of dazzling research techniques turns out to be modest or inconsistent. Schizophrenia is an anomaly at the frontier of mind and brain, but In Search of Madness begins to solve the mystery of how the brain produces mental life in the first place. -- from the publisher

Table of Contents:
1. Illness and Evidence
The Science of Schizophrenia
Rules of Evidence
2. The Nature of Symptoms
Psychiatric Pioneers
Symptoms and Diagnosis
The Mind of Madness
The Delusional World
Counterfeit Experience
Crazy Thoughts
General Summary and Conclusions
3. The Mark of Madness
Candidate Markers of Schizophrenia
Traits and States
Marking Genes
4. Executive Incompetence
The Search for the Schizophrenic Lesion
The Frontal Brain and Its Mind
Schizophrenia and the Frontal Mind
Pictures of the Brain
The Frontal-Executive Brain and its Contribution to Schizphrenia
5. The Biology of Meaning
The Temporal Lobe and its Semantic Functions
Schizophrenia and the Semantic Brain
Neurobiology of the Temporal Lobe in Schizophrenia
The Temporal-Semantic Brain and its Contribution to Schizophrenia
6. Neurochemical Tempest
Dopamine: Modulator of Mind and Movement
Serotonin: Chemical of Sleep and Moods
Glutamate: The Brain's Workhorse
General Summary and Conclusions
7. The Strangeness of Children
Essentials of Genetics and Early Neurodevelopment
Neurodevelopmental Evidence and Schizophrenia
Abnormalities of Children Vulnerable to Schizophrenia
Summary and Conclusions
8. Flights of Theory
Root Problems for Theories of Schizophrenia
Schizotaxia, Schizotypy and Schizophrenia
Neurodevelopmental Diathesis-Stress Theories
Summary and Synthesis
9. The End of the Beginning
The Neuroscience Sweepstakes
The Promissory Note
Multiple Disease States
The Anomaly at the Frontier of Mind and Brain

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