The most comprehensive text of its kind, this book addresses both the management of opioid withdrawal and opioid maintenance therapy, and combines up-to-date reviews of the scientific literature with evidence-based clinical guidelines for all of the relevant pharmacotherapies.
A unique work, Pharmacotherapies for the Treatment of Opioid Dependence presents: * detailed information on the cost-effectiveness of the various types of opioid treatment
* the range of pharmacotherapies used for the management of opioid dependence
* the state of knowledge from the international research literature on the value and relative efficacy of the various pharmacological approaches. This includes pharmacotherapies used in the management of withdrawal from opioids such as clonidine, lofexidine, methadone, buprenorphine and naltrexone and also symptomatic medications. It also includes different forms of maintenance therapy using opioid agonists such as methadone, LAAM, buprenorphine, slow-release oral morphine and diamorphine, and opioid antagonists such as naltrexone. This text should appeal to researchers, to identify gaps in the research literature and provide a basis for determining appropriate research directionspolicy makers, to clinicians by providing clinical with clinical guidelines and information concerning the empirical basis for the treatments, and to policy makers in assisting them to make decisions about the various treatments from a public health perspective, taking into account the relative cost and effectiveness of the interventions. --- from the publisher Contents: Section One: Introduction 1. Extent of Opioid Dependence and Management to Date 2. Pharmacology of Opioid Agonists and Antagonists Section Two: Outcomes for Withdrawal 3. Management of Heroin Withdrawal Section Three: Outcomes for Maintenance Treatment 4. Methadone Maintenance Treatment 5. LAAM Maintenance Treatment 6. Buprenorphine Maintenance Treatment 7. Other Forms of Opioid Agonist Maintenance Treatment 8. Naltrexone Maintenance/abstinence Orientated Therapy Section Four: Outcomes from the National Evaluation of Pharmacotherapies for Opioid Dependence (NEPOD) Project 9. Methodology of the NEPOD Project 10. The Relative Effectiveness of Withdrawal and Maintenance Treatments 11. Health Economic Methods and Outcomes Section Five: Process Issues 12. Pharmacotherapies and Pregnancy 13. Adjuvant Psychosocial Interventions and Rehabilitation 14. Assessing Opioid Dependent Patients and Matching Them to Treatment 15. Models of Service Delivery Section Six: Implementation Guidelines 16. Clinical Guidelines for Treatment with Methadone 17. Clinical Guidelines for Treatment with Buprenorphine 18. Clinical Guidelines for Treatment with LAAM 19. Clinical Guidelines for Treatment with Naltrexone Section Seven: Conclusion 20. Future Directions Author Biography: Richard P. Mattick is Director of Research, National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia. Prof. Mattick is Executive Editor of journal Drug and Alcohol Review and is Assistant Editor of the journal Addiction (previously British Journal of Addiction). | 
