A rich compendium that pulls together evidence from the basic and clinical neurosciences to provide an update on characteristics, comorbidity, potential causes , consequences and treatment of ADHD • Strong emphasis on translational research of ADHD, leading from science to evidence-based novel treatment and coping strategies • Offers a new paradigm for understanding ADHD • Contributing authors are international basic and clinical researchers The Behavioral Neuroscience of Attention Deficit Hyperactivity Disorder reviews the latest discoveries in research of ADHD. There is a strong emphasis on translational science, with preclinical approaches suggesting new directions for development of new treatments. Individual chapters describe how neuroimaging, neuroendocrine, genetic and behavioral studies use powerful research tools that are offering a completely new understanding of the factors that increase vulnerability to ADHD. The clinical impact of co-morbid problems, especially obesity and substance misuse, are highlighted and explain what such problems can tell us about the etiology of ADHD, more generally. Reviews of the pharmacology of established drug treatments for ADHD justify an exciting novel theory for their therapeutic actions and address questions about the effects of their long-term use. This volume is aimed at both clinicians and basic scientists, who are interested in ADHD, giving students and established researchers an overview of the current status of the field and insight into topics that will be prominent in the future. ADHD in Children and Adults: Diagnosis and Prognosis .................... 1 Renata Kieling and Luis A. Rohde ADHD: Volumetry, Motor, and Oculomotor Functions ..................... 17 E. Mark Mahone Neurodevelopmental Abnormalities in ADHD ............................... 49 Chandan J. Vaidya Intraindividual Variability in ADHD and Its Implications for Research of Causal Links .................................................. 67 Jonna Kuntsi and Christoph Klein Hypothalamic–Pituitary–Adrenocortical Axis Function in Attention-De?cit Hyperactivity Disorder .................................. 93 Graeme Fairchild Brain Processes in Discounting: Consequences of Adolescent Methylphenidate Exposure ................................................... 113 Walter Adriani, Francesca Zoratto, and Giovanni Laviola Attention De?cit Hyperactivity Disorder and Substance Use Disorders .................................................................. 145 Oscar G. Bukstein Linking ADHD, Impulsivity, and Drug Abuse: A Neuropsychological Perspective ..................................................................... 173 Gonzalo P. Urcelay and Jeffrey W. Dalley Obesity and ADHD: Clinical and Neurobiological Implications .......... 199 Samuele Cortese and Brenda Vincenzi Face Processing in Attention De?cit/Hyperactivity Disorder . . . . . . . . . . . . . . . 219 Daniel P. Dickstein and F. Xavier Castellanos Quantitative and Molecular Genetics of ADHD ............................ 239 Philip Asherson and Hugh Gurling Rodent Models of ADHD ..................................................... 273 Xueliang Fan, Kristy J. Bruno, and Ellen J. Hess Rat Models of ADHD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 301 Terje Sagvolden and Espen Borga° Johansen Epigenetics: Genetics Versus Life Experiences ............................. 317 Josephine Elia, Seth Laracy, Jeremy Allen, Jenelle Nissley-Tsiopinis, and Karin Borgmann-Winter Sexual Differentiation of the Brain and ADHD: What Is a Sex Difference in Prevalence Telling Us? ........................................ 341 Jaylyn Waddell and Margaret M. McCarthy ADHD: Current and Future Therapeutics .................................. 361 David J. Heal, Sharon L. Smith, and Robert L. Findling The Four Causes of ADHD: A Framework ................................. 391 Peter R. Killeen, Rosemary Tannock, and Terje Sagvolden Index ........................................................................... 427
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