This book provides an authoritative summary of current knowledge of the biological basis of substance use behaviours, including their relationship with environmental factors. The publication focuses on a wide range of psychoactive substances, including tobacco, alcohol and illicit drugs. New developments in neuroscience research are discussed, such as mechanisms governing craving, tolerance and neuroadaptation; immunotherapies and the concept of dependence, as well as the ethical implications of these developments. As the product of consultations with and contributions from many international experts and partners, the best available evidence is provided from the various schools of thought and areas of research in the field of neuroscience. --- from the publisher Contents: Brain mechanisms - neurobiology and neuroanatomy biobehavioural processes underlying dependence psychopharmacology of dependence for different drug classes genetic basis of substance dependence concurrent disorders ethical issues in neuroscience research on substance dependence, treatment and prevention health and social implications. |