Highlighting the importance of scientific progress in understanding the neurodevelopmental origins of psychopathology, this study presents the work of some of the most talented researchers in the field. Its chapters illustrate the interactional processes that characterize the genesis and maturation of the brain. They demonstrate how constitutional vulnerability to mental disorder can arise from the interplay of multiple factors. Dante Cicchetti and Elaine Walker offer invaluable perspectives for the pursuit of further research.
Part I. Basic Mechanisms in Prenatal, Perinatal and Postnatal Neurodevelopmental Processes and Their associations with High Risk Conditions and Adult Mental Disorders: 1. Principles of neurobehavioral teratology Linda Mayes and Anna Ward; 2. The neurodevelopmental consequences of very preterm birth: brain plasticity and its limits Chiara Nosarti, Larry Rifkin and Robin Murray; 3. Neurodevelopment during adolescence Linda Spear; 4. Prenatal risk factors for schizophrenia Alan S. Brown and Ezra S. Susser; 5. Obstetric complications and neurodevelopmental mechanisms in schizophrenia Tyrone Cannon and Isabelle M. Rosso; 6. Maternal influences on prenatal neural development contributing to schizophrenia Jason Shiffman, Sarnoff Mednick, Ricardo Machon, Matti Huttunen, Kay Thomas and Seymour Levine; Part II. Animal Models of Neurodevelopment and Psychopathology: 7. On the relevance of prenatal stress to developmental psychopathology: a primate model Mary L. Schneider, Colleen F. Moore and Gary W. Kraemer; 8. Nonhuman primate models of developmental psychopathology: problems and prospects Dario Maestripieri and Kim Wallen; 9. Early medial temporal dysfunction and autism Jocelyne Bachevalier and Katherine Loveland; Part III. Models of the Nature of Genetic and Environmental Influences on the Developmental Course of Psychopathology: 10. Genetic structure of neurodevelopmental traits: implications for the development and definition of psychopathology Richard Todd and John Constantino; 11. Prospects and problems in the search for genetic influences on neurodevelopment and psychopathology: application to childhood disruptive disorders Irwin Waldman; 12. Developmental psychoneuroimmunology: the role of cytokine network activation in the epigenesis of developmental psychopathology Doug Granger, Nancy A. Dreschel and Elizabeth A. Shirtcliff; 13. The hypothalamic-pituitary-adrenal system HPA and the development of aggressive, antisocial and substance abuse disorders Keith McBurnett, Jean King and Angela Scarpa; 14. Neuroendocrine functioning in maltreated children Dante Cicchetti; 15. Toward unraveling the premorbid neurodevelopmental risk for schizophrenia Matcheri Keshavan; 16. Interactions of the dopamine, serotonin and GABA systems during childhood and adolescence: influence of stress on the vulnerability for psychopathology Frances Benes; Part IV. The Neurodevelopmental Course of Illustrative High Risk Conditions and Mental Disorders: 17. Neurobiology of personality disorders: implications for a neurodevelopmental model Larry J. Siever, Harold W. Koenigsberg and Deidre Reynolds; 18. Genesis and epigenesis of psychopathology in children with depressed mothers: toward an integrative biopsychosocial perspective Sherryl H. Goodman; 19. The neurobiology of child and adolescent depression: current knowledge and future directions Joan Kaufman and Dennis Charney; 20. Psychosocial stressors as predisposing factors to affective illness and PTSD: potential neurobiological mechanisms and theoretical implications Robert Post, Gabriele S. Leverich, Susan R. B. Weiss, Li-Xin Zhang, Guoqiang Xing, He Li and Mark Smith; 21. Neurohormonal aspects of the development of psychotic disorders Elaine Walker and Deborah Walder.
Jocelyne Bachevalier, Francine Benes, Alan S. Brown, Tyrone Cannon, Dennis Charney, Dante Cicchetti, John Constantino, Nancy A. Dreschel, Sherryl H. Goodman, Doug Granger, Matti Huttunen, Joan Kaufman, Matcheri Keshavan, Jean King, Harold W. Koenigsberg, Gary W. Kraemer, Gabriele S. Leverich, Seymour Levine, He Li, Katherine Lovel, Ricardo Machon, Dario Maestripieri, Linda Mayes, Keith McBurnett, Sarnoff Mednick, Colleen F. Moore, Robin Murray, Chiara Nosarti, Robert Post, Deidre Reynolds, Larry Rifkin, Isabelle M. Rosso, Angela Scarpa, Mary L. Schneider, Jason Shiffman, Elizabeth A. Shirtcliff, Larry J. Siever, Mark Smith, Linda Spear, Ezra S. Susser, Kay Thomas, Richard Todd, Deborah Walder, Irwin Waldman, Elaine Walker, Kim Wallen, Anna Ward, Susan R. B. Weiss, Guoqiang Xing, Li-Xin Zhang