Understanding the phenomenon of long-lasting vulnerability to addiction is essential to developing successful treatments. Written by an international team of authorities in their respective fields, Advances in the Neuroscience of Addiction provides an excellent overview of the available and emerging approaches used to investigate the biologic mechanisms of drug addiction. It also delineates the promising research discoveries being made in relapse prevention.
The book begins with current animal models of addiction, which mimic the state of humans entering treatment: recently-abstinent animals that receive common triggers for relapse (classical conditioning, stress, and neuroadaptive dysregulation). Coverage then shifts to the use of electrophysiologic approaches, which enable researchers to characterize the discharge patterns of single neurons during drug self-administration. After exploring advances in voltammetry and enzyme-linked biosensors for measuring glutamate, the book discusses the theoretical background and results of neuroimaging studies related to neuronal networks that are activated by drug-specific cues. It then describes modern genetic approaches to manipulate target proteins that influence addictive behavior.
The book rounds out its coverage by illustrating how a neuroeconomic approach can inform studies of reward processing in general and addiction in particular. It is a comprehensive introduction to the methodologies of the field for students and beginning researchers and an essential reference source for established investigators.
Table of Contents
Advances in Animal Models of Relapse for Addiction Research
Application of Chronic Extracellular Recording Method to Studies of Cocaine Self-Administration: Method and Progress
Laura L. Peoples, Alexai V. Kravitz, and Karine Guillem
Neurochemistry of Addiction: Monitoring Essential Neurotransmitters of Addiction
Stefan G. Sandberg and Paul A. Garris
Alcohol Craving and Relapse Prediction: Imaging Studies
Andreas Heinz, Anne Beck, Jan Mir, Sabine M. Grüsser, Anthony A. Grace, and Jana Wrase
Integrating Behavioral and Molecular Approaches in Mouse:Self-Administration Studies
Danielle L. Graham and David W. Self
Neuroeconomics: Implications for Understanding the Neurobiology of Addiction
Michael L. Platt, Karli K. Watson, Benjamin Y. Hayden, Stephen V. Shepherd, and Jeffrey T. Klein
"In short, this volume introduces a host of important advances in the measurement of addictive processes at the genetic, physiological, neural, behavioral and psychological levels, as well as a wide variety of fascinating findings that will certainly play a major future role in both pure research and the pragmatics of treating addiction. Researchers at the forefront of addiction research will certainly want to consider the potential applications of these tools and findings for their own research."
About the Editors:
Cynthia M. Kuhn, Duke University Medical Center, Durham, North Carolina, USA
George F. Koob, The Scripps Research Institute, La Jolla, California, USA