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Frontal-Subcortical Circuits In Psychiatric and Neurological Disorders
Lichter, David and Jeffrey Cummings -Eds
Guilford Publications / Hardcover / 2000-11-01 / 1572306238
reg price: $151.95 our price: $ 129.16 (may be subject to change)
428 pages
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Contemporary research on the links between brain, mind, and human behavior has revealed the key role of the frontal-subcortical circuits in a wide range of neuropsychiatric syndromes and disorders. This authoritative volume reviews current knowledge on the anatomy of these circuits, their connections to other brain regions, and their influences on motor, cognitive, affective, and behavioral functioning. The volume first explains how the frontal-subcortical circuits provide a unifying organization of activities of the frontal lobes, basal ganglia, thalamus, and connecting white matter tracts. Specific clinical problems are then addressed, including Parkinson's disease and other movement disorders, obsessive-compulsive disorder, ADHD, schizophrenia, addictive disorders, and more. Chapters identify the neural substrates of specific symptoms, present salient human and animal data, and describe state-of-the- science approaches to pharmacological and neurosurgical intervention. Featured are a wealth of informative illustrations, including 8 pages in full color.

Table of Contents
1. Introduction and Overview, Lichter and Cummings
2. A Revised Neuroanatomy of Frontal- Subcortical Circuits, Middleton and Strick
3. Neurochemistry of Frontal-Subcortical Circuits, Bronstein and Cummings
4. Neurophysiology of Frontal-Subcortical Loops, Houk
5. Cognitive Abilities Mediated by Frontal- Subcortical Circuits, Salmon, Heindel, and Hamilton
6. Personality and Behavioral Changes with Frontal-Subcortical Dysfunction, Litvan
7. The Disinhibition Syndrome and Frontal- Subcortical Circuits, Starkstein and Kremer
8. Depression and Frontal-Subcortical Circuits: The Emerging Role of Prefrontal-Limbic Interactions,
9. Cortical-Subcortical Systems in the Mediation of Obsessive-Compulsive Disorder: Modeling the Brain's Mediation of a Classic "Neurosis," Baxter, Clark, Iqbal, and Ackermann
10. Addictions and Frontal-Subcortical Circuits, Capote, Flaherty, and Lichter
11. Movement Disorders and Frontal-Subcortical Circuits, Lichter
12. Frontal-Subcortical Circuits: A Functional Developmental Approach, Slattery, Garvey, and Swedo
13. Attention-Deficit/Hyperactivity Disorder as a Frontal/Subcortical Disorder, Voeller
14. The Role of Frontal-Subcortical Circuits in the Pathophysiology of Schizophrenia, West and Grace
15. Neuropsychopharmacology of Frontal- Subcortical Circuits, Bronstein and Cummings
16. Psychosurgery of Frontal-Subcortical Circuits, Weingarten and Cummings

"This elegant text addresses what is perhaps the most important conceptual development in late 20th-century neuropsychiatry....It explores the role of [frontal-subcortical circuits] in the primary manifestations of specific lesion-based neurologic syndromes and then, by extension, in the expression of virtually every major class of neuropsychiatric disorder. Specific dysfunction of intricate neurochemical and synaptic subterritories within the frontal- subcortical circuits must account for conditions as categorically distinct as depression, schizophrenia, OCD, substance abuse, ADHD, mania, and Tourette syndrome. Extrapolating from the signature syndromes of frontal-subcortical circuit dysfunction to the complexities of such neuropsychiatric states will require a much finer parsing of these circuits. This text can serve as a valuable primer for this process--a road map to the circuit 'interstates' as we move ahead to explore the neuronal side streets of the psyche."
-Neal R. Swerdlow, MD, PhD, School of Medicine, University of California, San Diego

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