A rich compendium that pulls together evidence from the basic and clinical neurosciences to provide an update on characteristics, comorbidity, potential causes , consequences and treatment of ADHD
• Strong emphasis on translational research of ADHD, leading from science to evidence-based novel treatment and coping strategies
• Offers a new paradigm for understanding ADHD
• Contributing authors are international basic and clinical researchers The Behavioral Neuroscience of Attention Deficit Hyperactivity Disorder reviews the latest discoveries in research of ADHD. There is a strong emphasis on translational science, with preclinical approaches suggesting new directions for development of new treatments. Individual chapters describe how neuroimaging, neuroendocrine, genetic and behavioral studies use powerful research tools that are offering a completely new understanding of the factors that increase vulnerability to ADHD. The clinical impact of co-morbid problems, especially obesity and substance misuse, are highlighted and explain what such problems can tell us about the etiology of ADHD, more generally. Reviews of the pharmacology of established drug treatments for ADHD justify an exciting novel theory for their therapeutic actions and address questions about the effects of their long-term use. This volume is aimed at both clinicians and basic scientists, who are interested in ADHD, giving students and established researchers an overview of the current status of the field and insight into topics that will be prominent in the future. ADHD in Children and Adults: Diagnosis and Prognosis .................... 1
Renata Kieling and Luis A. Rohde
ADHD: Volumetry, Motor, and Oculomotor Functions ..................... 17
E. Mark Mahone
Neurodevelopmental Abnormalities in ADHD ............................... 49
Chandan J. Vaidya
Intraindividual Variability in ADHD and Its Implications
for Research of Causal Links .................................................. 67
Jonna Kuntsi and Christoph Klein
Hypothalamic–Pituitary–Adrenocortical Axis Function
in Attention-De?cit Hyperactivity Disorder .................................. 93
Graeme Fairchild
Brain Processes in Discounting: Consequences of Adolescent
Methylphenidate Exposure ................................................... 113
Walter Adriani, Francesca Zoratto, and Giovanni Laviola
Attention De?cit Hyperactivity Disorder and Substance
Use Disorders .................................................................. 145
Oscar G. Bukstein
Linking ADHD, Impulsivity, and Drug Abuse: A Neuropsychological
Perspective ..................................................................... 173
Gonzalo P. Urcelay and Jeffrey W. Dalley
Obesity and ADHD: Clinical and Neurobiological Implications .......... 199
Samuele Cortese and Brenda Vincenzi
Face Processing in Attention De?cit/Hyperactivity Disorder . . . . . . . . . . . . . . . 219
Daniel P. Dickstein and F. Xavier Castellanos
Quantitative and Molecular Genetics of ADHD ............................ 239
Philip Asherson and Hugh Gurling
Rodent Models of ADHD ..................................................... 273
Xueliang Fan, Kristy J. Bruno, and Ellen J. Hess
Rat Models of ADHD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 301
Terje Sagvolden and Espen Borga° Johansen
Epigenetics: Genetics Versus Life Experiences ............................. 317
Josephine Elia, Seth Laracy, Jeremy Allen, Jenelle Nissley-Tsiopinis,
and Karin Borgmann-Winter
Sexual Differentiation of the Brain and ADHD: What Is a Sex
Difference in Prevalence Telling Us? ........................................ 341
Jaylyn Waddell and Margaret M. McCarthy
ADHD: Current and Future Therapeutics .................................. 361
David J. Heal, Sharon L. Smith, and Robert L. Findling
The Four Causes of ADHD: A Framework ................................. 391
Peter R. Killeen, Rosemary Tannock, and Terje Sagvolden
Index ........................................................................... 427
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